How Barrigel™
Rectal Spacer
Works
Rectal Spacer
Works
Significantly reduce rectal side effects of prostate radiation therapy with CLINICALLY PROVEN1 Barrigel™ rectal spacer.
The Importance of Space
Being located so close to the prostate puts the rectum at risk for radiation exposure.


Prostate cancer radiation therapy with Barrigel™ rectal spacer
Barrigel™ rectal spacer helps protect the rectum by reducing the amount of high-dose radiation that reaches it during treatment.1
How it Works
Barrigel™ rectal spacer is a biocompatible hyaluronic gel, placed between the prostate and rectum before radiation therapy starts.2-3,† The space created helps protect the rectum by moving it out of the high-dose radiation area.1
The spacer stays in place for the duration of your radiation therapy,1,2 and your body safely aborbs the gel over time.2,3
Minimize the side effects of prostate radiation therapy with Barrigel. Radiation therapy for the treatment of prostate cancer uses high energy beams to destroy and stop the spread of cancer cells. These high energy beams can negatively affect healthy tissues surrounding the prostate. Due to its close proximity to the prostate, the rectum is most at risk for radiation exposure. Barrigel Rectal Spacer can help minimize prostate radiation side effects by temporarily positioning the rectum away from the prostate. By creating space between the prostate and the rectum, Barrigel moves the healthy organ out of radiation beam exposure. Let's look at how Barrigel works. In rectal spacing, achieving complete and even coverage of the healthy tissue surrounding the prostate is crucial for protection from unwanted radiation exposure. The more even and consistent the rectal spacer, the more protection it provides the healthy tissue. Barrigel remains soft and pliable during insertion, your doctor to sculpt the spacer in place. The result is a custom implant tailored to your anatomy, offering more personalised coverage for more complete protection. Barrigel remains in place throughout the course of your radiation treatment, maintaining the space between your prostate and rectum until it is safely absorbed by your body. The seminal vesicles, which produce seminal fluid, are often exposed to radiation when treating prostate cancer. Protecting the rectum from seminal vesicle radiation exposure can help further reduce potential side effects. Barrigel is made from non animal stabilised hyaluronic acid known as NASHA. Hyaluronic acid is a substance naturally present in the human body and is highly and fully absorbable by the body. NASHA has been used for over two decades in more than fifty million procedures in men, women and children worldwide. To learn more about the benefits of Barrigel Rectal Spacer, visit barrigel.com.
See how Barrigel™ works to protect healthy rectal tissue from unwanted high-dose radiation exposure.
PERSONALIZED SPACING FOR OPTIMAL COVERAGE

Barrigel™ spacer is the only rectal spacer that can be sculpted to fit the unique contours of your anatomy.1,2,4-6 This advanced control helps your doctor create an even, consistent implant that provides optimal coverage1,2,5 between the prostate and rectum.
SAFE AND EFFECTIVE

To date, Barrigel™ spacer has been used in over 60,000†† cancer patients during prostate radiation therapy. Barrigel™ rectal spacer is made from Non-Animal Stabilized Hyaluronic Acid also known as NASHA.7
The NASHA Platform has a proven history of safety and efficacy and is used in many common medical procedures worldwide.†,2,3

References
- 1. Mariados NF, Orio PF III, King MT et al. JAMA Oncol (2023).*
2. Svatos M, Chell E, Low DA et al. Med Phys (2024)*
3. Restylane® celebrates 25 years of natural-looking results with its signature line of hyaluronic acid fillers. 2021
4. Williams J, Mc Millan K, Chao M et al. J Med Imag Radiat Sci (2022).
5. Gejerman G, Goldstein MM, Chao M et al. Pract Radiat Oncol (2023).**
6. Data on File. As of 4/01/2025.
7. Barrigel Injectable Gel Instructions for Use (2022).
8. King MT, Svatos M, Orio PF III et al. Pract Radiat Oncol (2023).*
*Study sponsored by Palette Life Sciences, now part of Teleflex.
**Drs Gejerman, Chao, Lederer, and Orio are paid consultants of Palette Life Sciences, now part of Teleflex.
†Barrigel, made from NASHA, is indicated for rectal spacing in prostate cancer patients and was FDA-cleared in May, 2022.
††Management estimate based on product sales as of January 2025