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Controlled Spacing with Barrigel Rectal Spacer What is controlled spacing in prostate cancer radiation therapy? The ability to create safe, anatomically-customized spacing for radiotherapy patients.1,2 Inherent Qualities: controllable sculptable flexible Controllable Barrigel rectal spacer gives you the ability to: Refine and adjust placement.1-4 in real-time.3,7 Sculptable Barrigel rectal spacer is sculptable, allowing customization throughout the procedure.1-3,5 Intentional Placement Barrigel rectal spacer allows for intentional placement, providing control over implant shape and placement.1-3,5 Controlled Spacing Results from the Barrigel Pivotal Trial.1 98.5% of patients achieved an average 85% dose reduction to the rectum (rV54) 20% of patients achieved 100% dose reduction to the rectum (rV54) Barrigel spacer was proven superior in the reduction of acute grade 2+ GI toxicity compared to control Zero (0) reports of implant migration For full study results please visit Barrigel.com IN RECTAL SPACING CONTROL MATTERS. References: Mariados NF, Orio PF III, King MT et al. JAMA Oncol (2023).*§ Svatos M, Chell E, Low DA et al. Med Phys (2024).*§ Gejerman G, Goldstein MM, Chao M et al. Pract Radiat Oncol (2023).§ Barrigel Injectable Gel Instructions for Use (2022). Williams J, Mc Millan K, Chao M et al. J Med Imaging Radiat Sci (2022).§ * Study sponsored by Palette Life Sciences, now part of Teleflex. § One or more of the authors are paid consultants of Teleflex.

What is controlled spacing in prostate cancer radiation therapy? The ability to create safe, anatomically-customized spacing for radiotherapy patients. Inherent qualities: Controllable. Sculptable. Flexible. Barrigel spacer has inherent lifting power. Dissects space on its own. In the Barrigel Pivotal Trial, ninety-five point six percent of implants had symmetric coverage. Achieve consistent results with Barrigel spacer. In rectal spacing, control matters. References. Mariados N F, Orio P F the third, King M et al. JAMA Oncology, 2023. Svatos M, Chell E, Low D A et al. Medical Physics, 2024. Williams J, McMillan K, Chao M et al. Journal of Medical Imaging and Radiation Sciences, 2022. Gejerman G, Goldstein M M, Chao M et al. Practical Radiation Oncology, 2023. Data on file. As of April first, two thousand twenty-five. Study sponsored by Palette Life Sciences, now part of Teleflex. One or more authors are paid consultants of Teleflex.

What is controlled spacing in prostate cancer radiation therapy? The ability to create safe, anatomically-customized spacing for radiotherapy patients. Inherent qualities: Controllable. Sculptable. Barrigel rectal spacer is inherently viscoelastic. Remains flexible during the body's natural activities, for example bowel movements, while maintaining implant shape. Controlled spacing results from the Barrigel Pivotal Trial. Ninety-seven point seven percent dimensional stability through three months. Nineteen point three percent resorption through three months. Maintains stable rectal separation during resorption. Bowel movements did not affect radiation results. In rectal spacing, control matters. References. Mariados N F, Orio P F the third, King M et al. JAMA Oncology, 2023. Svatos M, Chell E, Low D A et al. Medical Physics, 2024. King M T, Svatos M, Orio P F the third et al. Practical Radiation Oncology, 2023. One or more of the authors are paid consultants of Teleflex.

Does your rectal spacer provide you: Advanced control over implant placement. Does your rectal spacer provide you: The ability to sculpt with no time constraints. Does your rectal spacer provide you: Ninety-five point six percent symmetrical implant placement. In rectal spacing, control matters. References. Mariados N F, Orio P F the third, King M T et al. Implant test symetry results: ninety five point six (Barrigel) vs forty nine percent (PEG Hydrogel) JAMA Oncology, 2023. Svatos M, Chell E, King M T et al. Medical Physics, 2024. Gejerman G, Goldstein M M, Chao M et al. Practical Radiation Oncology, 2023. Williams J, McMillan K, Chao M et al. Journal of Medical Imaging and Radiation Sciences, 2022. Fischer-Valuck B W, Chundury A, Gay H, Bosch W, Michalski J. Practical Radiation Oncology, 2017. Study sponsored by Palette Life Sciences, now part of Teleflex. Barrigel is intended to temporarily position the anterior rectal wall away from the prostate during radiotherapy for prostate cancer. Barrigel is composed of biodegradable material and maintains space for the entire course of prostate radiotherapy treatment. Barrigel should only be administered by qualified and properly trained physicians with experience in ultrasound guidance and injection techniques in the urogenital pelvic area. As with any medical treatment, there are some risks involved with the use of Barrigel. Potential complications include pain, injection-related events, urinary retention, bleeding, constipation, rectal urgency, and other risks as described in the instructions for use. More information on indications, contraindications, warnings, and instructions for use can be found at Barrigel dot com. Caution: Federal law restricts this device to sale by or on the order of a physician.